Clinical/Research Interests:
Jeffrey P. Gregg's research laboratory is dedicated to understanding the genetic basis of cancer using two fundamental biological processes, the genetic predisposition for cancer and molecular alterations (changes in DNA, gene expression and protein) that occur in individual tumors. In searching for common genetic modifiers of cancer at the DNA level, Gregg is examining links between polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer. He uses innovative technology and informatics to study complex somatic changes in tumor formation, understand the underlying biology of cancer, and define better predictors for prognosis and responsiveness to clinical adjuvant modalities.
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Publications:
Gregg JP, Grody WW. Molecular pathology of the gastrointestinal tract The Peptide Letter 1999;8:11-15
Cheung VG, Gregg JP, Gogolins-Evans K, Bandong J, Stanley CA, Baker L, Nowak NJ, Shows TB, Ewens WJ, Nelson SF, Spielman RS Linkage- disequilibrium mapping without genotyping Nature Genetics 1998;18: 225-230
Welford S, Gregg JP, Garrison D, Denny C, Nelson SF. Coupling of representational differences analysis (RNA) to microarray screening to rapidly identify and confirm differentially expressed sequences Nucleic Acids Research 1998;26:3059-3065
Gregg JP. The use of a fluorescence scanner to monitor DNA microarrays Luminance Forum 1998;4:1-6
Geschwind DH, Gregg JP, Boone K, Karrim J, Pawlikowska-Haddal A, Rao E, Ellison J, Ciccodicola A, D’Urso M, Woods R, Rappold GA, Swerdloff R, Nelson SF. Klinefelter’s syndrome as a model of anomalous cerebral laterality: testing gene dosage in the X chromosome pseudoautosomal region using a DNA microarray Developing Genetics 1998;23:215-229
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